Editorial: pressure to close the therapeutic window of non-selective beta blockers? Authors’ reply

The Authors’ Reply

The Authors’ Reply

Nonselective Beta-blockers in Patients with Cirrhosis: "the Therapeutic Window".

For over 30 years, nonselective beta-blockers (NSBB) have been successfully used for preventing variceal bleeding in patients with cirrhosis and portal hypertension. Nevertheless, recent studies suggest that NSBB may be effective only within a particular "therapeutic window" in patients with advanced liver disease. Outside of this window, in early stages of cirrhosis and in very advanced cirrho...

The Authors’ Reply

Reply from Authors to the Editorial Comment

We read with interest the editorial comment by S. Daneshmand [1] regarding our recent article. The fact that lymph node metastases are found unexpectedly in the pathological specimens of up to 27% of patients with preoperatively staged cN0 muscle-invasive bladder cancer makes an extended pelvic lymph node dissection (ePLND) mandatory [2]. A significant number of these lymph node-positive patien...